• br Conclusions br Conflicts of interest br

  2021-10-09

  

  Conclusions Conflicts of interest Funding The research work was partially supported by National Science Center (Contract Grant Number: UMO-2015/19/B/NZ1/00332). Introduction Frusectose-1, 6-bisphosphatase (FBPase) has long been recognized as a potential therapeutic target for the treatm

• The RAS RAF MEK ERK pathway is a central controller

  2021-10-09

  

  The RAS/RAF/MEK/ERK pathway is a central controller of cell proliferation and survival and, consequently, alterations to some of its components lead to hyperactivation of the pathway, an event related to numerous types of cancer [172]. High rates of alterations to this pathway are found in leukemia

• It has been known for some

  2021-10-09

  

  It has been known for some time that an oral salt load given to mammals induces a much greater natriuresis than the intravenous administration of an equivalent amount of saline (Carey et al., 1976, Singer et al., 1998). In addition, oral administration of salt to rats has been reported to augmented

• AZ20 receptor The isoenzyme hGSTP is an attractive drug

  2021-10-09

  

  The isoenzyme hGSTP1-1 is an attractive drug target due to its high levels of disease association (target validation) and druggability (target tractability) properties [5,6,[17], [18], [19], [20], [21]]. hGSTP1-1 functions as a homodimer protein [18]. Each monomer has two domains, an α/β domain (N-t

• br Acknowledgements br Introduction The study methods consis

  2021-10-09

  

  Acknowledgements Introduction The study methods consisted of the review of articles included in the Pubmed and Medline databases and in the clinicaltrials.gov clinical trials register between 2013 and 2016, and of the preliminary results of therapies presented at international trichology confe

• Over expression of Glo can suppress inflammatory responses M

  2021-10-09

  

  Over-expression of Glo-1 can suppress inflammatory responses. Methylglyoxal mediates vascular inflammation in human endothelial RI-1 [33], indicating that Glo-1 may attenuate inflammation via eliminating methylglyoxal. Glo-1 knockdown mediated methylglyoxal accumulation provokes collagen expression

• VX-689 The role for noggin in telencephalic development and

  2021-10-09

  

  The role for noggin in telencephalic development and also adult neural stem cell expansion and differentiation has been debated, and noggin has been suggested to exert diverse effects in these events (Bachiller et al., 2000, Bonaguidi et al., 2008, Colak et al., 2008; de Chevigny et al., 2008, Li et

• br Vertebrate steroid receptor evolution br

  2021-10-09

  

  Vertebrate steroid receptor evolution Conclusion The teleost WGD event resulted in the duplication of the vertebrate GR and MR and two GRs have been retained in the majority of teleost fish studied so far. The molecular basis for this retention has yet to be fully understood. The cloning of th

• br Competing interests br Acknowledgements

  2021-10-09

  

  Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when 14613 is taken in orally as compared to infused intravenously [1]. Normally, the insulin respon

• In conclusion this is the first study

  2021-10-08

  

  In conclusion, this is the first study performed in acute limbic seizure models that shows the ability of DAG to dose-dependently attenuate pilocarpine-induced seizures, albeit at a higher concentration as ghrelin (Portelli et al., 2012b). We also establish that DAG's anticonvulsant mechanism of act

• C prevents the glutamate and erastin induced ROS accumulatio

  2021-10-08

  

  C16 prevents the glutamate- and erastin-induced ROS accumulation but does not affect the decrease in GSH, indicating that prevention of ROS accumulation by C16 is not due to the restoration of GSH levels. Instead, C16 itself possessed superoxide anion scavenging activity in vitro at similar concentr

• Therefore the histomorphology and the

  2021-10-08

  

  Therefore, the histomorphology and the comprehensive analysis of TMJ-RA pathogenesis need to be completed although clinical findings in TMJ-RA are similar to RA in other joints [41]. Especially for the dentist, the difficulties associated with diagnosing TMJ-RA patients [49] posing challenges to dia

• br Introduction Thrombosis is one of the leading causes

  2021-10-08

  

  Introduction Thrombosis is one of the leading causes of deaths in the cardiovascular diseases such as myocardial infarction (MI), unstable Caspase-6, human recombinant protein receptor and acute coronary syndrome (ACS) in developed countries [1], [2]. It is estimated that venous thromboembolism

• PDEs a group of metallophosphohydrolases hydrolyze the

  2021-10-08

  

  PDEs, a group of metallophosphohydrolases, hydrolyze the 3′,5′-cyclic phosphate group on cyclic nucleotides to a 5′-monophosphate, thereby blocking cyclic AMP (cAMP) or cGMP signaling [8,9]. There are different types of PDE isozymes, with different substrate specificities. PDE5 (specific to cGMP) an

• Continuing studies of endocannabinoid ligands at

  2021-10-08

  

  Continuing studies of endocannabinoid ligands at GPR55 reveal that virodhamine (O-arachidonylethanolamine) and AEA can act as a partial agonists at GPR55; at high micromolar concentrations can inhibit β-arrestin recruitment (Sharir et al., 2012). It is likely that there are allosteric as well as ort

16218 records 603/1082 page Previous Next First page 上5页 601602603604605 下5页 Last page