• Although HK localizes mainly to either the

  2022-08-05

  

  Although HK localizes mainly to either the cytosol or mitochondria [29], [30], [31] and cardioprotection is associated with increased mitochondrial HK binding, some studies have identified a component of HK located in intracellular vesicles within the cardiomyocyte [48], [61], supporting older data

• Tumor specific CD cytolytic T

  2022-08-05

  

  Tumor-specific CD8+ cytolytic T lymphocytes (CTLs) recognizing tumor antigenic peptide/major histocompatibility complexes-I (pMHC-I) presented on tumor cells play an important role in antitumor immunity [12]. However, immune tolerance including central (natural) or peripheral (acquired) tolerance be

• On the other hand after injury

  2022-08-05

  

  On the other hand, after injury of the adult heart, inflammatory monocytes are abundantly recruited to damaged myocardium and they differentiate into monocyte-derived macrophages (MDMs). They have strong proinflammatory phenotype and very limited capacity to promote angiogenesis and cardiomyocyte pr

• Acknowledgements br Introduction The neurotransmitter

  2022-08-05

  

  Acknowledgements Introduction The neurotransmitter glycine acts through two receptors: a strychnine-sensitive glycine receptor (GlyA) and a strychnine-insensitive glycine receptor (GlyB). GlyA is localized to the neuronal membrane post-synaptic to inhibitory glycinergic neurons, whereas GlyB is

• The calculations for the R substrate showed

  2022-08-05

  

  The calculations for the R substrate showed that, like the S substrate, the coordination shell of the Zn Immunology Compound Library is more symmetric than in the HIC-SG crystal structure. This symmetry indicates that the enzyme could use the same reaction mechanisms as for the S substrate, but wit

• br Methods br Results br

  2022-08-05

  

  Methods Results Discussion Significant alterations in the expression of genes related to the glutamatergic system have been shown in several experimental models of epilepsy; however, in most studies focused on acute changes or modifications in expression, these were investigated during the

• The observed increase in macroscopic conductance

  2022-08-05

  

  The observed increase in macroscopic conductance could be due to a left shift in the open state probability vs. voltage curve for the high-activity state causing an increase in the open state probability at all potentials. However, an increase of the apparent single channel conductance cannot be ent

• br Conflict of interest br Introduction Milk and dairy produ

  2022-08-05

  

  Conflict of interest Introduction Milk and dairy products are nutritious foods that provide lactose, calcium, phosphorous, magnesium and proteins, among other nutrients, which have been reported to have a fundamental role in bone development and healthy diets. An adequate consumption of dairy

• br Acknowledgments We apologize for the omission of primary

  2022-08-04

  

  Acknowledgments We apologize for the omission of primary citations owing to space limitations. This work was supported by grants from National Natural Science Foundation of China (81772801 and 81472455 to C.D.), the Key Program of Zhejiang Provincial Natural Science Foundation (LZ17H160002 to C.D

• The replenishment time course of already tethered

  2022-08-04

  

  The replenishment time course of already-tethered vesicle to became release ready, was examined by TIRFM imaging combined with calcium uncaging. By UV-flash photolysis of caged calcium, intracellular calcium concentration raises rapidly and homogenously throughout the cell (Ellis-Davies, 2008). Upon

• br Transportation from TGN toward plasma membrane The insuli

  2022-08-04

  

  Transportation from TGN toward plasma membrane The insulin molecules are packaged along with other molecules such as C-peptides, amylin, Zn2+, ATP and GABA in synaptic-like macrovesicles (SLMVs, with the diameters of 50–100 nm) and large dense core vesicles (LDCVs, with the diameters of 200–500 n

• Third across all three signaling molecules

  2022-08-04

  

  Third, across all three signaling molecules examined, the baseline abnormalities seen in Hdc-KO mice resemble the effects seen after H3R activation in wild-type animals. Specifically, MAPK activity (indexed by MSK1 phosphorylation) is increased at baseline in dMSNs of Hdc-KO mice to a similar degree

• br Tissue Specific Roles for HIF PHD

  2022-08-04

  

  Tissue-Specific Roles for HIF/PHD Isoforms Hypoxia signaling pathways are active in almost all mammalian cells, including immune GSK1016790A and tissues such as the epithelium and endothelium. This is of crucial importance when considering the influence of environmental hypoxia in inflammatory co

• br The value of a model of the complex forensic

  2022-08-04

  

  The value of a model of the complex forensic science matrix There have been various models proposed to address the complexity inherent to forensic reconstruction [15], [16], [17]. It is possible to argue that embracing the value of holistic models is important if we are to reclaim the ‘endeavour

• In summary we propose a

  2022-08-04

  

  In summary, we propose a model that explains the possible mechanism the HULC mediates activation of HBV in liver cancer BTB06584 (Fig. 8). In the model, HULC promotes the expression of miR-539 by stimulating HBx-co-activated STAT3. Then, miR-539 down-regulates APOBEC3B, leading to an increase of HB

16216 records 422/1082 page Previous Next First page 上5页 421422423424425 下5页 Last page