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br Discussion Light plays a central role
2022-09-29
Discussion Light plays a central role in plant growth, development and defence responses. It is required for photosynthesis and other metabolic or transcriptional processes (Kangasjärvi et al., 2012, Zhang and Zhou, 2013, Ballaré, 2014). It is well known that darkness promotes leaf senescence, wh
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Finally we find that in the absence of Aurora B
2022-09-29
Finally, we find that in the absence of Aurora B, Sgo1 is delocalized from centromeres and found along chromosome arms, as reported after depletion of Bub1 (Kitajima et al., 2005, Riedel et al., 2006). The increased arm cohesion observed in the absence of Aurora B activity is dependent on the presen
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It was noted elsewhere that several of
2022-09-29
It was noted elsewhere that several of the variants (i.e., Indel19 and SNP63) that make up the risk haplotypes had unusually large differences in allele frequencies between Africans and non-Africans, as compared with a set of likely neutral loci (Fullerton et al. 2002). This finding was interpreted
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While NR upregulation in the spinal cord is known
2022-09-28
While NR1 upregulation in the spinal cord is known to contribute to pathological pain [7], [22] and furthermore, NR1 expression in the spinal cord has been shown to be reduced by continuous administration of the GlyT1-inhibitor ALX5407 [23], little is known about possible expressional changes of NR1
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Brilliant Blue G br Acknowledgments br Introduction Manipula
2022-09-28
Acknowledgments Introduction Manipulating target protein expression via either induction or suppression of gene expression is a powerful technology that has been widely used in the recent past in the field of neurobiology, both to study the pathophysiological significance of a target gene and
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Dorsomorphin br Materials and methods br Results
2022-09-28
Materials and methods Results Discussion DNA repair pathways have evolved for a long time to act independently of one another. However, over the past decade several overlaps and crosstalks between these pathways were identified, showing that the DNA repair system is more complex than previo
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br Materials and methods br Results br Discussion To
2022-09-28
Materials and methods Results Discussion To the best of our knowledge, the current study presented the first evidence that GPR40, also named FFAR1, played an essential role in bone formation and mediated dapagliflozin induced osteogenic effect via Wnt/β-catenin signaling. We found that dos
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Glucose uptake a critical metabolic control
2022-09-28
Glucose uptake, a critical metabolic control point in glycolysis, is mediated by the GLUT (SLC2) family of integral membrane transporters (Mueckler and Thorens, 2013). GLUT1 (SLC2A1), one of the most well-studied members of the SLC2 family, exhibits a wide tissue distribution; cell surface expressio
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bapta It is important to underline that although ghrelin
2022-09-28
It is important to underline that bapta although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food intake and rewa
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Since the Gardos channel Ca sensor have been shown to
2022-09-28
Since the Gardos channel Ca2+ sensor have been shown to be constitutively bound calmodulin [16] and the PMCA is activated by association to a calcium–calmodulin complex, it seems probable that the NS309 agonist effect is caused by direct interaction with the Gardos channel, and not by an action on c
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The investigation in vitro revealed
2022-09-26
The investigation in vitro revealed that aldolase, as well as FBPase, has affinity to α-actinin, one of the structural protein of the Z-line (Rakus et al., 2003a, Mamczur et al., 2005). Therefore, the existence of in vivo heterologous complex, consisting of aldolase, FBPase and α-actinin has been po
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We characterized the enzyme corresponding to N FPP was the
2022-09-26
We characterized the enzyme corresponding to N1. FPP was the most effective substrate as allylic diphosphate, and the activities with GPP and DMAPP were 50% and 11% that with FPP, respectively. The analysis of the prenols resulting from the treatment of prenyl diphosphates with Dioscin phosphatase
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Structurally HMTs can be broadly categorized into
2022-09-24
Structurally, HMTs can be broadly categorized into three functional enzymatic families, the SET (Suppressor of variegation, Enhancer of zeste, Trithorax)-domain- containing methyltransferases, the non-SET DOT1-like (DOT1L) lysine methyltransferases, the PRDM family, containing a PR (PRDI-BF1-RIZ1 ho
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Introduction Histamine Imidazolyl ethylamine is an important
2022-09-24
Introduction Histamine [2-(4-Imidazolyl)-ethylamine] is an important mediator of many physiological and pathological processes including inflammation, gastric T16Ainh - A01 secretion, neuromodulation, regulation of immune function, cell proliferation and differentiation, among others. Histamine ex
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br Materials and methods br Results
2022-09-22
Materials and methods Results Discussion D. abbreviatus larvae are voracious feeders, and the nutrients consumed as part of their diet are broken by gut proteases and utilized for growth and development. Since proteases play an important role in larval and adult food digestion, it is import
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