• Long marginalised as a disorder confined to specific racial

  2019-06-28

  

  Long marginalised as a disorder confined to specific racial groups, sickle-cell disease is now assuming its rightful place as a major global public health problem. Most patients in the Americas, the Caribbean, and much of Europe have been of one racial group, which led to the common misconception th

• Another problem is that the indications

  2019-06-27

  

  Another problem is that the indications of each drug differ among Asia-Pacific countries, and it ONC201 is difficult to provide recommendations that are consistent with the indications in each country. For example, in Japan, the 3 novel OACs are indicated for “the prevention of ischemic stroke and

• In primary diagnosis IKZF status was not

  2019-06-27

  

  In primary diagnosis IKZF1 status was not taken into account for risk group stratification. According to protocol ALL-MB-2002 regulations, risk was underestimated and patient was assigned to the SRG. Prognostic value of IKZF1 alterations in ALL, especially BCR-ABL1 negative ALL, is still debated [19

• We are aware that physician

  2019-06-27

  

  We are aware that physician surveys have been previously used to assess; bisphosphonate use for bone pain [14], bisphosphonate use in metastatic breast cancer patients [15] and radiotherapy use for painful bone metastases [16] but are not aware of physician surveys being used to help design trials o

• br Dissemination permissive characteristics of the BM vascul

  2019-06-27

  

  Dissemination-permissive characteristics of the BM vascular niche Sinusoids (type L capillaries) are the most abundant blood vessels in bone and widely distributed throughout the bone marrow cavity [8]. Sinusoids in bone are discontinuous single layer of endothelial prostaglandin endoperoxide syn

• The appearance of J wave or

  2019-06-27

  

  The appearance of J wave or ER is now recognized to predispose to the development of arrhythmogenesis when associated with other cardiac disorders, such as ischemia, MK2 inhibitor failure, and hypothermia. The J wave might predict prognosis of cardiac events in various heart diseases, and the appea

• The most compelling apparent evidence in support of

  2019-06-27

  

  The most compelling apparent evidence in support of the depolarization hypothesis derives from the seminal studies of Nademanee et al. [129]. showing that radiofrequency ablation (RFA) of epicardial sites displaying late potentials and fractionated bipolar electrograms in the RVOT of patients with B

• Ya se alamos l neas arriba que el elogio

  2019-06-27

  

  Ya señalamos líneas arriba que el elogio respondía Dimethyl Fumarate una tradición primordialmente masculina. Ese rasgo se reproduce, claro está, en la RF, lo cual se explica fácilmente por las redes de sociabilidad que nutrían a esta revista y que esbozamos al principio de este artículo. La única e

• br Introduction Human endogenous retroviruses HERVs

  2019-06-27

  

  Introduction Human endogenous retroviruses (HERVs) are genetic remnants of ancient retroviral infections of the germ line produced during primate evolution which are now transmitted vertically. To date, approximately 8% of the human genome is composed of such retroviral sequences [1]. Most HERVs

• In this issue of Jun Zhu and colleagues report data

  2019-06-27

  

  In this issue of , Jun Zhu and colleagues report data retrieved from China\'s National Maternal Near Miss Surveillance System (NMNMSS), yielding a stillbirth rate of 8·8 per 1000 births for the Ropinirole HCl 2012–14. By comprehensively incorporating datasets based on level II (county or city distr

• El n mero de que corresponde al segundo

  2019-06-26

  

  El número 63 de , que corresponde al segundo semestre del presente año 2016, pone T0070907 disposición de la comunidad académica un conjunto variado de artículos sobre América Latina y un pequeño dedicado a la literatura brasileña. Eduardo Ayala Tafoya abre el número con “Lope de Aguirre: rebelión

• We describe a novel case wherein a

  2019-06-26

  

  We describe a novel case, wherein a patient with AML with inv (16) underwent allogeneic bone marrow transplantation from a related sibling donor which contained a small subpopulation of premalignant stem muscarinic receptor antagonists with trisomy 11. Fourteen years following transplantation, this

• Significant uncertainty remains about the precise vectors th

  2019-06-26

  

  Significant uncertainty remains about the precise vectors, the plasticity of vector host-selection (ie, monkey human) and the exact location of vector exposure that results in human transmission of especially across different parts of Asia. In particular, uncertainty exists as to whether transmiss

• The immunohistochemistry showed infiltration of CD T cells

  2019-06-26

  

  The immunohistochemistry showed infiltration of CD3+ T cells in dermis and few in the epidermis. The double staining of vitiligo biopsies by CD3+ and CD4+ showed that most of CD3+ cells are also CD4+. Whereas, CD3+/CD8+ are present in leading edge and lesional vitiligo skin and showing a mixture of

• Atrial fibrosis is one of the fundamental

  2019-06-26

  

  Atrial fibrosis is one of the fundamental mechanisms for the pathogenesis of atrial fibrillation (AF), but the underlying electrophysiological changes involved are not completely understood. Aging, neurohumoral activation, and chronic atrial stretch due to structural heart disease activate various

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